[HTML][HTML] HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity
An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is
associated with adverse pregnancy outcomes and all HIV-positive pregnant women …
associated with adverse pregnancy outcomes and all HIV-positive pregnant women …
In-depth analysis of physiologically based pharmacokinetic (PBPK) modeling utilization in different application fields using text mining tools
In the past decade, only a small number of papers have elaborated on the application of
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV
Objective: To evaluate dolutegravir pharmacokinetics during pregnancy compared with
postpartum and in infant washout samples after delivery. Design: Ongoing, nonrandomized …
postpartum and in infant washout samples after delivery. Design: Ongoing, nonrandomized …
Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV
Objective: To evaluate elvitegravir and cobicistat pharmacokinetics during pregnancy
compared with postpartum and in infant washout samples after delivery. Design …
compared with postpartum and in infant washout samples after delivery. Design …
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review
N Naidoo, J Moodley, T Naicker - Hypertension Research, 2021 - nature.com
This review assesses markers of endothelial dysfunction (ED) associated with the maternal
syndrome of preeclampsia (PE). We evaluate the role of antiretroviral therapy (ART) in …
syndrome of preeclampsia (PE). We evaluate the role of antiretroviral therapy (ART) in …
Sustained aviraemia despite anti-retroviral therapy non-adherence in male children following in utero hiv transmission
N Bengu, G Cromhout, E Adland, K Govender… - Nature Medicine, 2024 - nature.com
Following sporadic reports of post-treatment control of HIV in children who initiated
combination antiretroviral therapy (cART) early, we here prospectively studied 284 very …
combination antiretroviral therapy (cART) early, we here prospectively studied 284 very …
Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling
JJM Freriksen, S Schalkwijk, AP Colbers… - Clinical …, 2020 - Wiley Online Library
Antiretroviral therapy during pregnancy reduces the risk of vertical HIV‐1 transmission.
However, drug dosing is challenging as pharmacokinetics (PK) may be altered during …
However, drug dosing is challenging as pharmacokinetics (PK) may be altered during …
Low levels of tenofovir in breast milk support breastfeeding in HBV-infected mothers treated with tenofovir disoproxil fumarate
S Li, J Jin, Y Jiang, J Shi, X Jiang, N Lin, Z Ma - International Journal of …, 2023 - Elsevier
Objective Tenofovir disoproxil fumarate (TDF) is recommended for the prevention of mother-
to-infant transmission of the hepatitis B virus (HBV). This study investigated the safety of …
to-infant transmission of the hepatitis B virus (HBV). This study investigated the safety of …
Risk of birth defects and perinatal outcomes in HIV-infected women exposed to integrase strand inhibitors during pregnancy
J Sibiude, J Le Chenadec, L Mandelbrot, C Dollfus… - Aids, 2021 - journals.lww.com
Objectives: Following an alert on neural tube defects and dolutegravir, we sought to
evaluate if the exposure integrase strand transfer inhibitors (INSTIs) at conception was …
evaluate if the exposure integrase strand transfer inhibitors (INSTIs) at conception was …
Placental transfer and tissue accumulation of dolutegravir in the ex vivo human cotyledon perfusion model
Objective To determine the transplacental pharmacokinetics of the HIV integrase inhibitor
dolutegravir. Study design Maternal-to-fetal transfer across the term human placenta was …
dolutegravir. Study design Maternal-to-fetal transfer across the term human placenta was …