We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Treatment-resistant depression (TRD) typically refers to inadequate response to at least one
antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence …

Major depressive disorder is a debilitating disease. Unfortunately, treatment with
antidepressants (ADs) has limited therapeutic efficacy since resistance to AD is common …

Numerous studies have linked severe stress to the development of major depressive
disorder (MDD) and suicidal behaviors. Furthermore, recent preclinical studies from our …

There have been significant advances in the treatment of depression since the serendipitous
discovery that modulating monoaminergic neurotransmission may be a pathological …

Objective: To assess whether age, sex, burden of comorbid physical illness, age at onset,
history of recurrence, episode duration, chronic depression or comorbid dysthymia …

Background: The term “vascular depression” has been proposed to describe a subset of
depressive disorders that occurs in old age as a consequence of cerebrovascular disease …

Major depressive disorder is a prevalent recurrent medical syndrome associated with inter-
episodic dysfunction. The metabolic syndrome is comprised of several established risk …

Background Heterogeneity in overall response and outcomes to pharmacological treatment
has been reported in several depression studies but with few sources that integrate these …

An association between metabolic abnormalities, hypercholesterolemia and affective
disorders is now well recognized. Less well understood are the molecular mechanisms, both …