Pathogenesis and virulence of Candida albicans
JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …
[HTML][HTML] Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
[PDF][PDF] Hope on the horizon: novel fungal treatments in development
AM Rauseo, A Coler-Reilly, L Larson… - Open Forum Infectious …, 2020 - academic.oup.com
The treatment of invasive fungal infections remains challenging due to limitations in currently
available antifungal therapies including toxicity, interactions, restricted routes of …
available antifungal therapies including toxicity, interactions, restricted routes of …
[HTML][HTML] Lipid systems for the delivery of amphotericin B in antifungal therapy
C Faustino, L Pinheiro - Pharmaceutics, 2020 - mdpi.com
Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …
years, remains the gold standard in the treatment of life-threatening invasive fungal …
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …
Currently available antifungals include only five classes, and their utility and efficacy in …
Diagnosis and management of cryptococcal meningitis in HIV-infected adults
Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …
Oral lipid nanocrystal amphotericin B for cryptococcal meningitis: a randomized clinical trial
DR Boulware, M Atukunda, E Kagimu… - Clinical Infectious …, 2023 - academic.oup.com
Background Amphotericin B is the gold standard treatment for severe mycoses. A new orally
delivered, less-toxic formulation of amphotericin has been developed. Methods In our …
delivered, less-toxic formulation of amphotericin has been developed. Methods In our …
[HTML][HTML] Antifungal pipeline
TP McCarty, PG Pappas - Frontiers in cellular and infection …, 2021 - frontiersin.org
In many ways, fungal diseases are forgotten or neglected. Given the significantly lower
frequency compared to similar bacterial etiologies across the spectrum of infectious …
frequency compared to similar bacterial etiologies across the spectrum of infectious …
[HTML][HTML] Therapies and vaccines based on nanoparticles for the treatment of systemic fungal infections
B Kischkel, SA Rossi, SR Santos… - Frontiers in cellular …, 2020 - frontiersin.org
Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal
therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of …
therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of …
[HTML][HTML] Novel antifungal agents in clinical trials
SE Jacobs, P Zagaliotis, TJ Walsh - F1000Research, 2021 - ncbi.nlm.nih.gov
Invasive fungal diseases due to resistant yeasts and molds are an important and increasing
public health threat, likely due to a growing population of immunosuppressed hosts …
public health threat, likely due to a growing population of immunosuppressed hosts …