Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

The effects of oxytocin on appetite regulation, food intake and metabolism in humans

L Kerem, EA Lawson - International Journal of Molecular Sciences, 2021 - mdpi.com
The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological
processes, including parturition, lactation, cell growth, wound healing, and social behavior …

Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish

I Akinrinade, K Kareklas, MC Teles, TK Reis… - Science, 2023 - science.org
Emotional contagion is the most ancestral form of empathy. We tested to what extent the
proximate mechanisms of emotional contagion are evolutionarily conserved by assessing …

Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial

H Yamasue, M Kojima, H Kuwabara, M Kuroda… - Brain, 2022 - academic.oup.com
Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of
autism spectrum disorder, which has currently no approved medication, the efficacy of …

Sniffing oxytocin: Nose to brain or nose to blood?

S Yao, Y Chen, Q Zhuang, Y Zhang, C Lan, S Zhu… - Molecular …, 2023 - nature.com
In recent years ample studies have reported that intranasal administration of the
neuropeptide oxytocin can facilitate social motivation and cognition in healthy and clinical …

Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

N Daniels, M Moerkerke, J Steyaert, A Bamps… - Molecular Autism, 2023 - Springer
Background Intranasal administration of oxytocin is increasingly explored as a new
approach to facilitate social development and reduce disability associated with a diagnosis …

Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action

S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
Acute and chronic administration of intranasal oxytocin and vasopressin have been
extensively utilized in both animal models and human preclinical and clinical studies over …

In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
Intranasal oxytocin exerts wide-ranging effects on socioemotional behavior and is proposed
as a potential therapeutic intervention in psychiatric disorders. However, following intranasal …

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …

Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain
and various psychiatric disorders, however, there is scant evidence that oxytocin reaches …