Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

N 6-methyladenosine (m6A) is the most abundant internal modification on mammalian
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …

Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …

BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …