PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

ME Abd El‐Hack, MT El‐Saadony… - Journal of the …, 2021 - Wiley Online Library
Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as
an aromatic stimulant, a food preservative, and coloring material. The commonly used …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects

RR Kotha, DL Luthria - Molecules, 2019 - mdpi.com
Turmeric is a curry spice that originated from India, which has attracted great interest in
recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin …

SIRT1 activation by natural phytochemicals: an overview

C Iside, M Scafuro, A Nebbioso, L Altucci - Frontiers in pharmacology, 2020 - frontiersin.org
Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

Antimicrobial potential of curcumin: therapeutic potential and challenges to clinical applications

Y Hussain, W Alam, H Ullah, M Dacrema, M Daglia… - Antibiotics, 2022 - mdpi.com
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known
for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that …

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

AB Kunnumakkara, D Bordoloi… - British journal of …, 2017 - Wiley Online Library
Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective

D Ezhilarasan - Arab Journal of Gastroenterology, 2018 - Elsevier
Oxidative stress plays an important role in the pathogenesis of various chronic liver diseases
(CLD) and increasing evidence have confirmed the contributory role of oxidative stress in …

Neuroprotective activities of curcumin in Parkinson's disease: a review of the literature

EE Nebrisi - International journal of molecular sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting
dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized …

Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS Pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …