Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of
an individual and, when present, his or her disease. It has a host of targets, including genes …

In recent decades, there has been a major shift in the way researchers process and
understand scientific data. Digital access to data has revolutionized ways of doing science in …

Supervised neural networks have been applied as a machine learning technique to identify
and predict emergent patterns among multiple variables. A common criticism of these …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation …

The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Since at least the middle of the past century, one overarching model of psychiatric
classification has reigned supreme, namely, that of the Diagnostic and Statistical Manual of …

'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …