The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

We established an international consortium to review and discuss relevant clinical evidence
in order to develop expert consensus statements related to cancer management during the …

COVID-19 is not deadly early in life, but mortality increases exponentially with age, which is
the strongest predictor of mortality. Mortality is higher in men than in women, because men …

Allergies are rapidly worsening in recent decades, representing the most common
immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis …

Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

Inflammation is a key component in the pathogenesis of cardiovascular diseases causing a
significant burden of morbidity and mortality worldwide. Recent research shows that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the global
pandemic of coronavirus disease 2019 (COVID-19) and particularly exhibits severe …

Regulatory T cells (Tregs) have the role of regulating self-tolerance, and suppressing
immune responses. Defects in Treg function and number can lead to in loss of tolerance or …

Abstract Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). A single-stranded RNA virus from a β …