[HTML][HTML] A fun-guide to innate immune responses to fungal infections

TB Burgess, AM Condliffe, PM Elks - Journal of Fungi, 2022 - mdpi.com
Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

[HTML][HTML] Human airway epithelium responses to invasive fungal infections: A critical partner in innate immunity

AJ Crossen, RA Ward, JL Reedy, MV Surve, BS Klein… - Journal of Fungi, 2022 - mdpi.com
The lung epithelial lining serves as the primary barrier to inhaled environmental toxins,
allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry …

Pseudolaric acid B ameliorates fungal keratitis progression by suppressing inflammation and reducing fungal load

M Yin, N Li, L Zhang, J Lin, Q Wang, L Gu… - ACS Infectious …, 2023 - ACS Publications
This study aimed to determine the mechanisms of antifungal and anti-inflammation effects of
pseudolaric acid B (PAB) on Aspergillus fumigatus (A. fumigatus) keratitis. In vitro MIC assay …

Serum Cytokine Biomarkers for Use in Diagnosing Pulmonary Tuberculosis versus Chronic Pulmonary Aspergillosis

W Ren, H Li, C Guo, Y Shang, W Wang… - Infection and Drug …, 2023 - Taylor & Francis
Background Aspergillus fumigatus-induced chronic pulmonary aspergillosis (CPA), the most
common pulmonary tuberculosis (TB) sequela, tends to occur after pulmonary infection with …

[HTML][HTML] Respiratory epithelial cells: more than just a physical barrier to fungal infections

BCSC Barros, BR Almeida, DTL Barros, MS Toledo… - Journal of Fungi, 2022 - mdpi.com
The respiratory epithelium is highly complex, and its composition varies along the
conducting airways and alveoli. In addition to their primary function in maintaining the …

[HTML][HTML] Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis

BN Steffan, D Calise, SC Park, M Niu, J Yang… - Frontiers in …, 2023 - frontiersin.org
Background Aspergillus fumigatus is a well-known opportunistic pathogen that causes a
range of diseases including the often-fatal disease, invasive pulmonary aspergillosis (IPA) …

Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

M Bertuzzi, GJ Howell, DD Thomson, R Fortune-Grant… - bioRxiv, 2022 - biorxiv.org
Hundreds of spores of the common mould A spergillus f umigatus (Af) are inhaled daily by
human beings, representing a constant, often fatal, threat to our respiratory health. The small …

Dysbiosis of lower respiratory tract microbiome are associated with proinflammatory states in non‐small cell lung cancer patients

Y Li, G Rao, G Zhu, C Cheng, L Yuan, C Li… - Thoracic …, 2024 - Wiley Online Library
Background The lung has a sophisticated microbiome, and respiratory illnesses are greatly
influenced by the lung microbiota. Despite the fact that numerous studies have shown that …

TRAF3 gene regulates macrophage migration and activation by lung epithelial cells infected with Aspergillus fumigatus

S Shang, D He, C Liu, X Bao, S Han… - Microbiology …, 2024 - Am Soc Microbiol
Aspergillus fumigatus is an opportunistic pathogen that infects immunocompromised
patients and imposes a heavy burden on global health. Searching for key genes in host …

Comparison of serum cytokine profiles of patients with pulmonary tuberculosis and aspergillus infections

W Ren, H Li, C Guo, Y Shang, W Wang, X Zhang, S Li… - 2022 - researchsquare.com
Objectives: aspergillus fumigatus induced chronic pulmonary aspergillosis (CPA) is the most
common sequelae of pulmonary tuberculosis (TB), which caused by intracellular infection …