Aspects of matrix effects in applications of liquid chromatography–mass spectrometry to forensic and clinical toxicology—a review
FT Peters, D Remane - Analytical and Bioanalytical Chemistry, 2012 - Springer
In the last decade, liquid chromatography coupled to (tandem) mass spectrometry (LC–MS
(− MS)) has become a versatile technique with many routine applications in clinical and …
(− MS)) has become a versatile technique with many routine applications in clinical and …
Stability of analytes in biosamples—an important issue in clinical and forensic toxicology?
FT Peters - Analytical and bioanalytical chemistry, 2007 - Springer
Abstract Knowledge of the stability of drugs in biological samples is important for the
interpretation of toxicological findings. This paper reviews data on the stability of drugs in …
interpretation of toxicological findings. This paper reviews data on the stability of drugs in …
Effect of mexiletine on muscle stiffness in patients with nondystrophic myotonia evaluated using aggregated N-of-1 trials
BC Stunnenberg, J Raaphorst, HM Groenewoud… - Jama, 2018 - jamanetwork.com
Importance In rare diseases it is difficult to achieve high-quality evidence of treatment
efficacy because of small cohorts and clinical heterogeneity. With emerging treatments for …
efficacy because of small cohorts and clinical heterogeneity. With emerging treatments for …
Simultaneous determination of eight β-lactam antibiotics in human serum by liquid chromatography–tandem mass spectrometry
T Ohmori, A Suzuki, T Niwa, H Ushikoshi… - … of Chromatography B, 2011 - Elsevier
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed
for the simultaneous determination of eight β-lactam antibiotics, including ampicillin …
for the simultaneous determination of eight β-lactam antibiotics, including ampicillin …
[HTML][HTML] Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring
Y Gui, Y Lu, S Li, M Zhang, X Duan, CC Liu, J Jia… - Scientific reports, 2020 - nature.com
Therapeutic drug monitoring (TDM) is necessary for the optimal administration of anti-
arrhythmic drugs in the treatment of heart arrhythmia. The present study aimed to develop …
arrhythmic drugs in the treatment of heart arrhythmia. The present study aimed to develop …
Determination of five antiarrhythmic drugs in human plasma by dispersive liquid–liquid microextraction and high-performance liquid chromatography
A fast and sensitive high-performance liquid chromatography (HPLC) method with ultraviolet
(UV) detection was developed and validated for the simultaneous quantitation of five …
(UV) detection was developed and validated for the simultaneous quantitation of five …
Fragmentation of toxicologically relevant drugs in positive‐ion liquid chromatography–tandem mass spectrometry
WMA Niessen - Mass Spectrometry Reviews, 2011 - Wiley Online Library
The identification of drugs and related compounds by LC–MS–MS is an important analytical
challenge in several application areas, including clinical and forensic toxicology, doping …
challenge in several application areas, including clinical and forensic toxicology, doping …
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric …
Y Zhang, N Mehrotra, NR Budha, ML Christensen… - Clinica chimica acta, 2008 - Elsevier
BACKGROUND: Acetaminophen, caffeine, phenytoin, ranitidine, and theophylline are
widely used in pediatric pharmacotherapy, but only very limited information is available on …
widely used in pediatric pharmacotherapy, but only very limited information is available on …
Simultaneous determination of bisoprolol and hydrochlorothiazide in human plasma by HPLC coupled with tandem mass spectrometry
MF Tutunji, HM Ibrahim, MH Khabbas… - … of Chromatography B, 2009 - Elsevier
A sensitive, specific and selective method has been developed for the simultaneous
determination of bisoprolol and hydrochlorothiazide in human plasma. The method …
determination of bisoprolol and hydrochlorothiazide in human plasma. The method …
Carvedilol
K Beattie, G Phadke, J Novakovic - Profiles of drug substances, excipients …, 2013 - Elsevier
Abstract Carvedilol ((2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy) ethyl] amino]
propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and …
propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and …