Analysis of carvedilol enantiomers in human plasma using chiral stationary phase column and liquid chromatography with tandem mass spectrometry

JC Poggi, FG Da Silva, EB Coelho, MP Marques… - Chirality, 2012 - Wiley Online Library
Carvedilol is an antihypertensive drug available as a racemic mixture.(−)‐(S)‐carvedilol is
responsible for the nonselective β‐blocker activity but both enantiomers present similar …

Fast and sensitive analysis of beta blockers by ultra‐high‐performance liquid chromatography coupled with ultra‐high‐resolution TOF mass spectrometry

J Tomková, P Ondra, E Kocianová… - Biomedical …, 2017 - Wiley Online Library
This paper presents a method for the determination of acebutolol, betaxolol, bisoprolol,
metoprolol, nebivolol and sotalol in human serum by liquid–liquid extraction and ultra‐high …

A Sensitive Liquid Chromatography-Mass Spectrometric Method for Determination of Bisoprolol in Rat Serum after Pre-Column Derivatization

HA Shaheen, SO Bahaffi… - Journal of …, 2023 - academic.oup.com
Two derivatization regents were reacted with bisoprolol (BIS), followed by liquid-
chromatography-mass spectrometric analysis. 3-Bromomethyl-propyphenazone (BMP) and …

Absorption barriers in the rat intestinal mucosa: 1. Application of an in situ perfusion model to simultaneously assess drug permeation and metabolism

DR Mudra, RT Borchardt - Journal of Pharmaceutical Sciences, 2010 - Elsevier
Modulation of intestinal drug absorption barriers can have a profound impact on the
bioavailability of orally administered compounds. With its commonality of use as an …

Development of a validated spectrofluorimetric method for assay of sotalol hydrochloride in tablets and human plasma: application for stability-indicating studies

FA Ibrahim, AM El-Brashy, MI El-Awady… - Open …, 2019 - degruyter.com
The native fluorescence of sotalol hydrochloride (SOT) was used as a basis for establishing
a new method of analysis for SOT in tablets and spiked human plasma. The fluorescence of …

[PDF][PDF] Visible spectrophotometric method for estimation of bisoprolol from its bulk and tablet formulation

ST Kumbhar, PP Shinde, DB Shinde… - Asian J Pharm Clin …, 2013 - academia.edu
The proposed method is new, simple, sensitive, reproducible, economical, accurate and
precise and can be successfully applied in estimation of bisoprolol. This method can find …

Development and validation of a liquid chromatography–mass spectrometry method for simultaneous determination of metoprolol and telmisartan in rat plasma and its …

U Nandi, S Dan, TK Pal - Journal of Pharmaceutical Investigation, 2015 - Springer
A simple, rapid and sensitive high-performance liquid chromatography–tandem mass
spectrometry method has been developed and validated according to the Food and Drug …

Detection of acute overdose states by some antihypertensive drugs using gas chromatography-mass spectrometry

ES Melnikov, MV Belova, GV Ramenskaya - Journal of Analytical …, 2014 - Springer
Abstracts A method is developed for the detection of some antihypertensive drugs, atenolol,
bisoprolol, enalapril, metoprolol, nifedipine and propranolol by gas chromatography coupled …

[引用][C] 微流控芯片毛细管电泳激光诱导荧光检测法测定片剂中盐酸美西律的含量

孙悦, 彭怀东, 魏惠燕, 张玉英, 王淑美 - 分析试验室, 2012

Liquid chromatography tandem mass spectrometry method for determination of bisoprolol in human plasma using d5‐bisoprolol as the internal standard

G Liu, W Wang, J Jia, C Lu, Y Liu… - Biomedical …, 2010 - Wiley Online Library
A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC‐
MS/MS) protocol was developed and validated for quantification of bisoprolol in human …