Despite decades of research and anti-tobacco messaging, nicotine addiction remains an
important public health problem leading to hundreds of thousands of deaths each year …

Tobacco smoking is the leading cause of preventable death and disease. Although there are
some FAD-approved medicines for controlling smoking, the relapse rate remains very high …

Mood disorders, including major depressive disorder (MDD), are the most prevalent
psychiatric illnesses, and pose an incredible burden to society, both in terms of disability and …

Though vaping likely represents a safer alternative to smoking, it is not without risks, many of
which are not well understood, especially for vulnerable populations. Here we evaluate the …

Sex differences in behaviors relevant to nicotine addiction have been observed in rodent
models and human subjects. Behavioral, imaging, and epidemiological studies also suggest …

Introduction Nicotine addiction remains a primary health concern as tobacco smoking
remains the number one cause of preventable death in America. At the same time, America …

While combustible cigarette smoking has declined, the use of electronic nicotine delivery
systems (ENDS) has increased. ENDS are popular among adolescents, and chemical …

Rationale Translational research, especially research that bridges studies with humans and
nonhuman species, is critical to advancing our understanding of human disorders such as …

Introduction Smoking and the use of other nicotine-containing products is rewarding in
humans. The self-administration of nicotine is also rewarding in male rats. However, it is …

The α2a-adrenergic receptor (α2a-AR) agonist guanfacine has been investigated as a
potential treatment for substance use disorders. While decreasing stress-induced …