New drugs are not enough‑drug repositioning in oncology: An update
RG Armando… - … Journal of Oncology, 2020 - spandidos-publications.com
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …
are already known for use treating other diseases. The advantages of this are that several …
Drug repositioning in glioblastoma: a pathway perspective
SK Tan, A Jermakowicz, AK Mookhtiar… - Frontiers in …, 2018 - frontiersin.org
Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …
Repurposing chlorpromazine to treat COVID-19: The reCoVery study
Objectives The ongoing COVID-19 pandemic has caused approximately 2,350,000
infections worldwide and killed more than 160,000 individuals. In Sainte-Anne Hospital …
infections worldwide and killed more than 160,000 individuals. In Sainte-Anne Hospital …
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine
Introduction Urgent action is needed to fight the ongoing coronavirus disease 2019 (COVID-
19) pandemic by reducing the number of infected cases, contagiousness and severity …
19) pandemic by reducing the number of infected cases, contagiousness and severity …
A novel computational approach for drug repurposing using systems biology
Motivation Identification of novel therapeutic effects for existing US Food and Drug
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Administration (FDA)-approved drugs, drug repurposing, is an approach aimed to …
Repurposing psychiatric drugs as anti-cancer agents
J Huang, D Zhao, Z Liu, F Liu - Cancer letters, 2018 - Elsevier
Cancer is a major public health problem and one of the leading contributors to the global
disease burden. The high cost of development of new drugs and the increasingly severe …
disease burden. The high cost of development of new drugs and the increasingly severe …
Phase 1 lead‐in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed …
S Maraka, MD Groves, AG Mammoser… - Cancer, 2019 - Wiley Online Library
Background Repurposed memantine, mefloquine, and metformin have putative anticancer
activity. The objective of this phase 1 study was to determine the maximum tolerated doses …
activity. The objective of this phase 1 study was to determine the maximum tolerated doses …
Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target
Repurposing the large arsenal of existing non‐cancer drugs is an attractive proposition to
expand the clinical pipelines for cancer therapeutics. The earlier successes in repurposing …
expand the clinical pipelines for cancer therapeutics. The earlier successes in repurposing …
Drug repurposing for glioblastoma and current advances in drug delivery—a comprehensive review of the literature
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with an
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
extremely poor prognosis. There is a dire need to develop effective therapeutics to …
Repurposing drugs for glioblastoma: from bench to bedside
Glioblastoma multiforme is the most common, aggressive and lethal type of brain tumor. It is
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …