Among primary brain tumors, malignant gliomas are notably difficult to manage. The higher-
grade tumors represent an unmet need in medicine. There have been extensive efforts to …

Clinical studies have shown that treating many primary brain tumors is challenging due in
part to the lack of safe and effective compounds that cross the blood brain barrier (BBB)(Tan …

Despite their low incidence rate globally, high-grade gliomas (HGG) remain a fatal primary
brain tumor. The recommended therapy often is incapable of resecting the tumor entirely …

Patients with glioblastoma (GBM) often suffer from symptomatic epilepsy. Older antiepileptic
drugs (AEDs) which affect the enzyme system cytochrome P450 have been in extensive use …

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of
14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent …

Résumé Objectifs La pandémie mondiale actuelle de COVID-19 a touché environ 2 350 000
personnes et fait plus de 160 000 morts. Nous avons observé dans le GHU de Paris …

Chlorpromazine, an antipsychotic medication, is conventionally applied to cope with the
psychotic disorder such as schizophrenia. In cellular studies, chlorpromazine exerts many …

Despite the vast amounts of information gathered about gliomas, the overall survival of
glioma patients has not improved in the last four decades. This could partially be due to an …

Glioblastoma (GBM) is the most common and malignant type of primary brain tumor,
showing rapid development and resistance to therapies. On average, patients survive 14.6 …