Options for first‐line chemotherapy in patients with metastatic colorectal carcinoma have
broadened considerably with the introduction of irinotecan and oxaliplatin. Furthermore, the …

Metastatic colorectal cancer (mCRC) carries a poor prognosis with an overall 5-year survival
of 13.1%. Therapies guided by tumor profiling have suggested benefit in advanced cancer …

Purpose: Recently, an objective response rate of 12% was reported in a phase II study of
cetuximab in patients with epidermal growth factor receptor (EGFR)-expressing metastatic …

Fatty acid composition in plasma captures both dietary intake and endogenous synthesis.
Prospective analyses of plasma fatty acid composition are needed to establish the role of …

ABSTRACT CD4+ CD25+ regulatory T (Treg) cells are engaged in the maintenance of
immunological self-tolerance and suppressive control of excessive immune responses to …

Hypoxic induction of gene expression occurs mainly via the hypoxia-inducible factor-1 (HIF-
1) transcription factor and is a critical step in tumor growth. Cyclooxygenase-2 (COX-2) is …

This case–control study of 310 colorectal cancer cases and 1177 controls in a nested
prospective, population-based cohort of Singapore Chinese subjects found a statistically …

Colorectal cancer is the third most frequent cause of cancer worldwide and is more
prevalent in older individuals of all ages. The recent statistics from World Health …

Experimental data support multiple roles for fatty acids in colorectal carcinogenesis. We
examined dietary fatty acids and incidence of colorectal cancer, and evaluated effect …

There is now increasing evidence that a constitutive expression of cyclooxygenase 2 (COX-
2) plays a role in the development and progression of malignant ectodermal tumours. In this …