The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Nearly a century after the significance of the human complement system was recognized, we
have come to realize that its functions extend far beyond the elimination of microbes …

Porphyromonas gingivalis is a low-abundance oral anaerobic bacterium implicated in
periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions …

Background The complement cascade not only provides protection from infection but can
also mediate destructive inflammation. Complement is also involved in elimination of …

Dairy cattle are susceptible to increased incidence and severity of both metabolic and
infectious diseases during the periparturient period. A major contributing factor to increased …