Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been
studied extensively. Experimental studies showing the permissive role of GH/insulin-like …

Background Acromegaly is a rare and underdiagnosed disorder caused, in more than 95%
of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Objective To compare the acromegaly mortality rates with those expected for the general
population from studies published before and after 2008. Methods We performed a …

Several components of the GH axis are involved in tumor progression, and GH-induced
intracellular signaling has been strongly associated with breast cancer susceptibility in …

Context Acromegaly is a rare disease associated with chronic multisystem complications.
National registries have been created in several countries. Design The French Registry …

Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1
(GH/IGF-1) axis are associated with increased life-and healthspan across model organisms …

Breast cancer is one of the most common cancers diagnosed in women. Approximately two-
thirds of all breast cancers diagnosed are classified as hormone dependent, which indicates …

Context Whether cancer risk in acromegaly is increased remains controversial, and the risk
of benign tumors has been little studied. Objective To investigate the incidence of benign …