Organ preservation: current concepts and new strategies for the next decade
EE Guibert, AY Petrenko, CL Balaban… - Transfusion Medicine …, 2011 - karger.com
Organ transplantation has developed over the past 50 years to reach the sophisticated and
integrated clinical service of today through several advances in science. One of the most …
integrated clinical service of today through several advances in science. One of the most …
Strategies to improve long-term outcomes after renal transplantation
M Pascual, T Theruvath, T Kawai… - … England Journal of …, 2002 - Mass Medical Soc
This article provides a comprehensive, up-to-date review of methods to prevent early and
late renal-allograft loss and to improve long-term outcomes in patients. The authors focus …
late renal-allograft loss and to improve long-term outcomes in patients. The authors focus …
Normothermic ex vivo lung perfusion in clinical lung transplantation
Background More than 80% of donor lungs are potentially injured and therefore not
considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion …
considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion …
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non …
G Warnecke, D Van Raemdonck, MA Smith… - The Lancet …, 2018 - thelancet.com
Background Severe primary graft dysfunction (PGD) of grade 3 (PGD3) is a common serious
complication following lung transplantation. We aimed to assess physiological donor lung …
complication following lung transplantation. We aimed to assess physiological donor lung …
Technique for prolonged normothermic ex vivo lung perfusion
M Cypel, JC Yeung, S Hirayama, M Rubacha… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: The inhibition of cellular metabolism induced by hypothermia obviates the
possibility of substantial reparative processes occurring during organ preservation. The aim …
possibility of substantial reparative processes occurring during organ preservation. The aim …
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
JL Martin, ASH Costa, AV Gruszczyk, TE Beach… - Nature …, 2019 - nature.com
During heart transplantation, storage in cold preservation solution is thought to protect the
organ by slowing metabolism, providing osmotic support and minimizing ischaemia …
organ by slowing metabolism, providing osmotic support and minimizing ischaemia …
[HTML][HTML] Activation of immune signals during organ transplantation
Q Li, P Lan - Signal transduction and targeted therapy, 2023 - nature.com
The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …
[HTML][HTML] Experience with the first 50 ex vivo lung perfusions in clinical transplantation
OBJECTIVE: Normothermic ex vivo lung perfusion is a novel method to evaluate and
improve the function of injured donor lungs. We reviewed our experience with 50 …
improve the function of injured donor lungs. We reviewed our experience with 50 …
[HTML][HTML] Organ preservation: from the past to the future
Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …
Preservation solutions and techniques are crucial for donor organ quality, which is directly …
Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications
In the pursuit of dendrimer alternatives, hyperbranched polymers have found increasing
interest from academia and industry in a broad range of fields due to their topological and …
interest from academia and industry in a broad range of fields due to their topological and …