The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Curcumin, isolated from Curcuma longa L., is a fat-soluble natural compound that can be
obtained from ginger plant tuber roots, which accumulative evidences have demonstrated …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma
longa belonging to the family zingiberaceae. Growing experimental evidence revealed that …

Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …

Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes
progressive disability in the elderly. Reactive oxygen species (ROS) play an important role …

The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2)
transcription factor is a key player in cytoprotection and activated in stress conditions caused …

Background Modern pharmacological research found that the chemical components of
Curcuma longa L. are mainly curcumin and turmeric volatile oil. Several recent randomized …

Drug-induced nephrotoxicity contributes to acute kidney injury (AKI) and represents a major
problem in the clinical setting. We investigated the possible involvement of NLRP3 …

Introduction Quercetin was recently reported to help protect against osteoarthritis (OA)
progression, but the molecular mechanism for that protective affect remains unclear …