Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Viral entry and fertilization are distinct biological processes that share a common
mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell …

Coronavirus disease-2019 (COVID-19), a potentially lethal respiratory illness caused by the
coronavirus SARS-CoV-2, emerged in the end of 2019 and has since spread aggressively …

Liposomes represent important drug carrier vehicles in biological systems. A fusogenic
liposomal system composed of equimolar mixtures of the cationic lipid DOTAP and the …

SARS‐CoV‐2 may enter target cells through the process of membrane fusion at either the
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …

N-terminal residues (770–788) of the S2 glycoprotein of severe acute respiratory syndrome
coronavirus (SARS-CoV) have been recognized as a potential fusion peptide that can be …

COVID-19, caused by SARS-CoV-2, which is a positive-sense, single-stranded RNA
enveloped virus, emerged in late 2019 and was declared a worldwide pandemic in early …

Membrane-active peptides (MAPs) possess unique properties that make them valuable tools
for studying membrane structure and function and promising candidates for therapeutic …

Viral proteases are an important target for drug development, since they can modulate vital
pathways in viral replication, maturation, assembly and cell entry. With the (re) appearance …

Understanding fusion mechanisms employed by SARS-CoV-2 spike protein entails realistic
transmembrane domain (TMD) models, while no reliable approaches towards predicting the …