Regulation of antioxidants in cancer

F Hecht, M Zocchi, F Alimohammadi, IS Harris - Molecular Cell, 2024 - cell.com
Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Glutathione metabolism and Parkinson's disease

M Smeyne, RJ Smeyne - Free Radical Biology and Medicine, 2013 - Elsevier
It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Glutathione transferases

JD Hayes, JU Flanagan… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

CE Boström, P Gerde, A Hanberg… - Environmental …, 2002 - ehp.niehs.nih.gov
Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion.
Domestic wood burning and road traffic are the major sources of PAHs in Sweden. In …

Glutathione transferases, regulators of cellular metabolism and physiology

PG Board, D Menon - Biochimica et biophysica acta (bba)-general subjects, 2013 - Elsevier
BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review

AE Edris - … Research: An International Journal Devoted to …, 2007 - Wiley Online Library
Essential oils and their volatile constituents are used widely to prevent and treat human
disease. The possible role and mode of action of these natural products is discussed with …

The role of glutathione-S-transferase in anti-cancer drug resistance

DM Townsend, KD Tew - Oncogene, 2003 - nature.com
Abstract Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes
that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and …

The multifaceted role of glutathione S-transferases in cancer

A Chatterjee, S Gupta - Cancer letters, 2018 - Elsevier
Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the
maintenance of cell integrity, oxidative stress and protection against DNA damage by …

[HTML][HTML] The Nrf2 system as a potential target for the development of indirect antioxidants

KA Jung, MK Kwak - Molecules, 2010 - mdpi.com
Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Glutathione S-transferase polymorphisms and their biological consequences

JD Hayes, RC Strange - Pharmacology, 2000 - karger.com
Two supergene families encode proteins with glutathione S-transferase (GST) activity: the
family of soluble enzymes comprises at least 16 genes; the separate family of microsomal …