Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria

P Gowda, PH Reddy, S Kumar - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …

Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview

A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

[HTML][HTML] Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease

Y Açar, D Ağagündüz, P De Cicco… - Biomedicine & …, 2023 - Elsevier
Abstract Parkinson's Disease (PD), a neurodegenerative disorder, is characterized by the
degeneration of progressive dopaminergic (DA) neurons in the substantia nigra region of …

MicroRNAs and apoptosis in colorectal cancer

H Wang - International journal of molecular sciences, 2020 - mdpi.com
Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its
incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to …

MicroRNA schizophrenia: etiology, biomarkers and therapeutic targets

HC Zhang, Y Du, L Chen, ZQ Yuan, Y Cheng - … & Biobehavioral Reviews, 2023 - Elsevier
The three sets of symptoms associated with schizophrenia—positive, negative, and
cognitive—are burdensome and have serious effects on public health, which affects up to …

Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities

J Prasuhn, RL Davis, KR Kumar - Frontiers in cell and developmental …, 2021 - frontiersin.org
The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α …

TK Motawi, RH Al-Kady, SM Abdelraouf… - Chemico-Biological …, 2022 - Elsevier
Empagliflozin, a selective sodium-glucose co-transporter-2 inhibitor, has been demonstrated
to provide additional non-glycemic benefits, including neuroprotection. Endoplasmic …

MicroRNA-21 is a versatile regulator and potential treatment target in central nervous system disorders

X Bai, Z Bian - Frontiers in molecular neuroscience, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNAs with a
length of approximately 22 nucleotides that are found in eukaryotes. miRNAs are involved in …

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson's disease

OA Mohammed, MS Elballal, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Parkinson's disease (PD) is a debilitating neurological disorder characterized by the
impairment of the motor system, resulting in symptoms such as resting tremor, cogwheel …

Targeting epigenetic modifications in Parkinson's disease therapy

D Zhang, J Zhang, Y Wang, G Wang… - Medicinal Research …, 2023 - Wiley Online Library
Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …