Adolescence is the developmental epoch during which children become adults–
intellectually, physically, hormonally, and socially. Adolescence is a tumultuous time, full of …

The laws governing cannabis are evolving worldwide and associated with changing
patterns of use. The main psychoactive drug in cannabis is Δ 9-tetrahydrocannabinol (THC) …

The major mechanism for generating diversity of neuronal connections beyond their genetic
determination is the activity-dependent stabilization and selective elimination of the initially …

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the
reasons for this remain debated. Methods: We applied a Cox proportional hazards model to …

Despite extensive study over the past decades, available treatments for schizophrenia are
only modestly effective and cause serious metabolic and neurological side effects …

Background The growing concern about cannabis use, the most commonly used illicit drug
worldwide, has led to a significant increase in the number of human studies using …

The observation that antagonists of the N-methyl-D-aspartate receptor (NMDAR), such as
phencyclidine (PCP) and ketamine, transiently induce symptoms of acute schizophrenia had …

Questions surrounding the effects of chronic marijuana use on brain structure continue to
increase. To date, however, findings remain inconclusive. In this comprehensive study that …

The dose-dependent toxicity of the main psychoactive component of cannabis in brain
regions rich in cannabinoid CB1 receptors is well known in animal studies. However …

During adolescence, both rodent and human studies have revealed dynamic changes in the
developmental trajectories of corticolimbic structures, which are known to contribute to the …