Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Background—Hemodynamic load regulates myocardial function and gene expression. We
tested the hypothesis that afterload and preload, despite similar average load, result in …

It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Cardiovascular diseases (CVDs) are common causes of death, which take about 18.6
million lives worldwide every year. Currently, exploring strategies that delay ventricular …

Cardiac progenitors, such as cardiospheres and cardiosphere-derived cells, represent an
attractive cell source for cardiac regeneration. The PIWI-interacting RNAs, piRNAs, are an …

This study tested the hypothesis that exercise training would prevent the development of
diabetes-induced cardiac dysfunction and altered expression of sarcoplasmic reticulum …

Background—Puma (p53-upregulated modulator of apoptosis) is a proapoptotic Bcl-2 family
protein that serves as a general sensor in response to pathological apoptotic stimuli. In …

This study examined sex differences in the regulation of pro-and anti-apoptotic proteins in
cardiac hypertrophy and heart failure due to volume overload induced by arteriovenous (AV) …

Acute decompensated heart failure (ADHF) is responsible for more than 1 million hospital
admissions each year in the US. Clinicians and scientists have developed therapeutic …