Background Persistent systemic infection results in excessive trafficking of peripheral
immune cells into the central nervous system (CNS), thereby contributing to sustained …

La esclerosis múltiple es la enfermedad inflamatoria, crónica y degenerativa más frecuente
del sistema nervioso central y representa la primera causa de discapacidad en adultos …

Autoimmune inflammation of the limbic gray matter structures of the human brain has
recently been identified as major cause of mesial temporal lobe epilepsy with interictal …

Testosterone is essential to human growth and development as well as immune regulation.
Zika virus (ZIKV), an emerging arbovirus associated with neurological complications …

Granzyme A (gzmA), a serine protease involved in the modulation of the inflammatory
immune response, is found at an elevated level in the serum from ALS patients. However …

A fundamental question in neuroimmunology is the extent to which CD8 T cells actively
engage virus-infected neurons. In the Theiler's murine encephalomyelitis virus (TMEV) …

An increasing number of neurologic diseases is associated with autoimmunity. The immune
effectors contributing to the pathogenesis of such diseases are often unclear. To explore …

Background Neural-antigen reactive cytotoxic CD8+ T cells contribute to neuronal
dysfunction and degeneration in a variety of inflammatory CNS disorders. Facing excess …

Relapsing–remitting multiple sclerosis (RRMS), secondary progressive (SP) MS and primary
progressive (PP) MS patients showed higher percentages of circulating CD8+ CD56 …

Abstract Background CD4+ CD25+ forkhead box P3 (FoxP3)+ regulatory T cells (T reg cells)
are known to suppress adaptive immune responses, key control tolerance and …