The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

Alzheimer's disease (AD) patients exhibit progressive disruption of entrained circadian
rhythms and an aberrant circadian input pathway may underlie such dysfunction. Here we …

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

The behavioral and psychological symptoms of dementia (BPSD) are challenging aspects of
dementia care. This study used machine learning models to predict the occurrence of BPSD …

Light therapy has been used as a non-pharmacologic treatment to modulate biorhythms in
patients with mental and psychological conditions. These conditions include affective …

Aging, polypharmacy (concurrent use of≥ 5 medications), and functional impairment are
global healthcare challenges. However, knowledge of the age/sex-specific effects of …

Objectives It is believed that inadequate environmental light, especially in facilities such as
care homes, contribute to the diurnal changes of behavioural and psychological symptoms …

Background: Many identified mechanisms could be upstream of the prominent amyloid-β
(Aβ) plaques in Alzheimer's disease (AD). Objective: To profile the progression of pathology …

Background: The term sundowning is used to describe the emergence or worsening of
neuropsychiatric symptoms in late afternoon or early evening in people with dementia …