Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …