Chronic hypoxia induces polycythemia, pulmonary hypertension, right ventricular
hypertrophy, and weight loss. Hypoxia-inducible factor 1 (HIF-1) activates transcription of …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and
oxygen homeostasis is an organizing principle for understanding metazoan evolution …

The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor
suppressor in a subset of human renal cell carcinomas. Human FH-deficient cancer cells …

BACKGROUND Animals and land plants are the most diverse complex multicellular life-
forms on Earth, and their success intricately links a capacity for adhering cells to perform …

Tumor progression occurs as a result of the clonal selection of cells in which somatic
mutations have activated oncogenes or inactivated tumor suppressor genes leading to …

Hypoxia is an important factor that elicits numerous physiological and pathological
responses. One of the major gene expression programs triggered by hypoxia is mediated …

Of all the chemical elements, oxygen is the most vital to the human body. The brain is the
most sensitive organ to oxygen deprivation (hypoxia), which, over an extended period, can …

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …

Mesenchymal stem cells/multipotent stromal cells (MSCs) are promising therapeutics for a
variety of conditions. However, after transplantation, cell retention remains extremely …