Oxygen depravation in mammals leads to the transcriptional induction of a host of target
genes to metabolically adapt to this deficiency, including erythropoietin and vascular …

The central nervous system (CNS) is a major dose-limiting organ in clinical radiotherapy
(XRT). The underlying mechanisms of radiation-induced injury in this organ remain unclear …

The origin of several vascular pathologies involves sudden or recurrent oxygen deficiency.
In this review, we examine what the biochemical and molecular responses of the endothelial …

Heme oxygenase (HO) is responsible for the physiological breakdown of heme into
equimolar amounts of biliverdin, carbon monoxide, and iron. Three isoforms (HO‐1, HO‐2 …

Atherosclerosis is a major contributor to cardiovascular disease, and genetic disorders of
lipoprotein metabolism are recognized risk factors in atherogenesis. The gaseous …

Hypoxia-inducible factor-1 (HIF-1) is a dimeric transcriptional complex that has been
recognized primarily for its role in the maintenance of oxygen and energy homoeostasis …

Iron chelators are pluripotent neuronal antiapoptotic agents that have been shown to
enhance metabolic recovery in cerebral ischemia models. The precise mechanism (s) by …

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master
regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively …

Heme oxygenase-1 (HO-1), an enzyme degrading heme to carbon monoxide, free iron, and
biliverdin, participates in the cell defence against oxidative stress and it has been …

Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling
are revealing an unexpected physiological role for CO in the cardiovascular, immune and …