In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Sepsis often leads to multiple organ failure or even death and is a significant health problem
that contributes to a heavy economic burden. The lung is the first organ to be affected by …

Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant
types of cell death that largely account for the development of cardiac ischemia reperfusion …

SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …

There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore …

Innate immunity normally provides excellent defence against invading microorganisms.
Acute inflammation is a form of innate immune defence and represents one of the primary …

Simple Summary The canonical WNT/β-catenin pathway is upregulated in cancers and
plays a major role in proliferation, invasion, apoptosis and angiogenesis. Recent studies …

Background Autophagy is a dynamic physiological process that can generate energy and
nutrients for cell survival during stress. Autophagy can regulate the migration and invasive …