Exploring the expanding universe of small RNAs

J Shi, T Zhou, Q Chen - Nature cell biology, 2022 - nature.com
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Classical and noncanonical functions of miRNAs in cancers

MP Dragomir, E Knutsen, GA Calin - Trends in Genetics, 2022 - cell.com
Alterations in microRNAs (miRNAs) expression are causative in the initiation and
progression of human cancers. The molecular events responsible for the widespread …

Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

[PDF][PDF] VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

B Barman, BH Sung, E Krystofiak, J Ping, M Ramirez… - Developmental Cell, 2022 - cell.com
RNA transfer via extracellular vesicles (EVs) influences cell phenotypes; however, lack of
information regarding biogenesis of RNA-containing EVs has limited progress in the field …

[HTML][HTML] Advances in understanding N-glycosylation structure, function, and regulation in health and disease

S Esmail, MF Manolson - European journal of cell biology, 2021 - Elsevier
N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …

Metabolic glycoengineering–exploring glycosylation with bioorthogonal chemistry

M Kufleitner, LM Haiber, V Wittmann - Chemical Society Reviews, 2023 - pubs.rsc.org
Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

Spatial imaging of glycoRNA in single cells with ARPLA

Y Ma, W Guo, Q Mou, X Shao, M Lyu, V Garcia… - Nature …, 2023 - nature.com
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …

Demystifying the O-GlcNAc code: a systems view

J Ma, C Hou, C Wu - Chemical Reviews, 2022 - ACS Publications
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

A Nanopore‐Based Saccharide Sensor

S Zhang, Z Cao, P Fan, Y Wang, W Jia… - Angewandte Chemie …, 2022 - Wiley Online Library
Saccharides play critical roles in many forms of cellular activities. Saccharide structures are
however complicated and similar, setting a technical hurdle for direct identification …