Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …

Colorectal cancer (CRC) is considered as the second most common cancer worldwide. For
the past few years, the role of immunotherapy has been extensively studied and it has been …

The development of pancreatic cancer requires recruitment and activation of different
macrophage populations. However, little is known about how macrophages are attracted to …

During development of pancreatic cancer macrophage-mediated inflammatory processes
and the formation of cancerous lesions are tightly connected. Based on insight from mouse …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Background Desmoplastic stroma, a feature of pancreatic ductal adenocarcinoma (PDAC),
contains abundant activated pancreatic stellate cells (PSCs). How PSCs promote PDAC …

Simple Summary Despite access to a vast arsenal of anticancer agents, many fail to realise
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …

The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma
(PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of metastasis …

Pancreatic stellate cells (PSCs) are activated in pancreatic ductal adenocarcinoma (PDAC)
and are responsible for dense desmoplastic stroma. Yes-associated protein 1 (YAP1) can …

Simple Summary The incidence of pancreatic cancer is increasing but there has been little
progress in the diagnosis and survival rates of this lethal cancer for decades. Understanding …