Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel
growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Background: Out of 3 billion base pairs in human genome only~ 2% code for proteins; and
out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Left ventricular noncompaction (LVNC) causes prominent ventricular trabeculations and
reduces cardiac systolic function. The clinical presentation of LVNC ranges from …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Tumor endothelial cells (ECs) promote cancer progression in ways beyond their role as
conduits supporting metabolism. However, it is unknown how vascular niche-derived …

The advancement of natural-based biomaterials in providing a carrier has revealed a wide
range of benefits in the biomedical sciences, particularly in wound healing, tissue …