Parvalbumin‐containing GABAergic interneurons in the striatum, electrophysiologically
identified as fast‐spiking interneurons (FSIs), exert inhibitory control over striatal output to …

Aggressive behavior is usually adaptive, and so it preserves, and leaves a biological
footprint. When this genetically encoded but epigenetically regulated trait is predominantly …

In this work, we develop models of neural circuits and plasticity rules that underlie different
forms of learning and memory, with a focus on learning processes that involve multiple brain …

Compulsive and repetitive behaviors in obsessive-compulsive spectrum disorders (OCSDs)
are associated with perturbations in the sensorimotor striatum. Repetitive behaviors are …

Sports related concussions and mild traumatic brain injuries have seen an increase in
frequency over the past decade. The creation of highly biofidelic computational head models …

Neural networks, whether artificial in a computer or natural in the brain, could represent
information either using discrete symbols or continuous vector spaces. In this thesis, I …

Cognitive training offers a potential approach for the prevention of cognitive decline in later
life. Repetition of targeted exercises may improve, or at least preserve, both specific domain …

Quality of life largely depends on the outcomes of our decisions. A common model for
understanding decision-making is reinforcement learning. Reinforcement learning involves …

The dorsomedial striatum (DMS) plays a key role in action selection, but little is known about
how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs) contribute to …

Psychotic symptoms, a key feature of Schizophrenia, can have a significant impact on safety
and quality of life for patients. Despite years of research, the pathophysiology of psychotic …