[HTML][HTML] Injection of a dopamine type 2 receptor antagonist into the dorsal striatum disrupts choices driven by previous outcomes, but not perceptual inference

E Lee, M Seo, O Dal Monte… - Journal of …, 2015 - Soc Neuroscience
Decisions are often driven by a combination of immediate perception and previous
experience. In this study, we investigated how these two sources of information are …

Dead rats, dopamine, performance metrics, and peacock tails: proxy failure is an inherent risk in goal-oriented systems

YJ John, L Caldwell, DE McCoy… - Behavioral and Brain …, 2024 - cambridge.org
When a measure becomes a target, it ceases to be a good measure. For example, when
standardized test scores in education become targets, teachers may start “teaching to the …

[HTML][HTML] Action-value comparisons in the dorsolateral prefrontal cortex control choice between goal-directed actions

RW Morris, A Dezfouli, KR Griffiths… - Nature communications, 2014 - nature.com
It is generally assumed that choice between different actions reflects the difference between
their action values yet little direct evidence confirming this assumption has been reported …

Prefrontal cortical inactivations decrease willingness to expend cognitive effort on a rodent cost/benefit decision-making task

JG Hosking, PJ Cocker, CA Winstanley - Cerebral Cortex, 2016 - academic.oup.com
Personal success often necessitates expending greater effort for greater reward but, equally
important, also requires judicious use of our limited cognitive resources (eg, attention) …

[HTML][HTML] Brain-inspired meta-reinforcement learning cognitive control in conflictual inhibition decision-making task for artificial agents

F Robertazzi, M Vissani, G Schillaci, E Falotico - Neural Networks, 2022 - Elsevier
Conflictual cues and unexpected changes in human real-case scenarios may be detrimental
to the execution of tasks by artificial agents, thus affecting their performance. Meta-learning …

[HTML][HTML] Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases

J Algermissen, JC Swart, R Scheeringa… - Nature …, 2024 - nature.com
Actions are biased by the outcomes they can produce: Humans are more likely to show
action under reward prospect, but hold back under punishment prospect. Such motivational …

Caudate stimulation enhances learning

SK Bick, SR Patel, HA Katnani, N Peled, A Widge… - Brain, 2019 - academic.oup.com
Neuromodulation is a promising treatment modality for disorders of learning and memory,
offering the possibility of precise alteration of disordered neural circuits. Studies to date have …

[HTML][HTML] Regulating Prefrontal Cortex Activation: An Emerging Role for the 5-HT2A Serotonin Receptor in the Modulation of Emotion-Based Actions?

S Aznar, AB Klein - Molecular neurobiology, 2013 - Springer
The prefrontal cortex (PFC) is involved in mediating important higher-order cognitive
processes such as decision making, prompting thereby our actions. At the same time, PFC …

Thalamocortical contribution to flexible learning in neural systems

MB Wang, MM Halassa - Network neuroscience, 2022 - direct.mit.edu
Animal brains evolved to optimize behavior in dynamic environments, flexibly selecting
actions that maximize future rewards in different contexts. A large body of experimental work …

[HTML][HTML] Aberrant neural signatures of decision-making: Pathological gamblers display cortico-striatal hypersensitivity to extreme gambles

SV Gelskov, KH Madsen, TZ Ramsøy, HR Siebner - NeuroImage, 2016 - Elsevier
Pathological gambling is an addictive disorder characterized by an irresistible urge to
gamble despite severe consequences. One of the hallmarks of pathological gambling is …