[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects
T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …
[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …
impairment and blindness globally. Drug administration through the topical ocular route is …
[HTML][HTML] Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …
tissues continues to be a key challenge for formulation scientists. Various attempts are …
Nanomaterial-based ophthalmic drug delivery
G Xie, S Lin, F Wu, J Liu - Advanced drug delivery reviews, 2023 - Elsevier
The low bioavailability and side effects of conventional drugs for eye disease necessitate the
development of efficient drug delivery systems. Accompanying the developments of …
development of efficient drug delivery systems. Accompanying the developments of …
[HTML][HTML] Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy
M Wu, W Huang, N Yang, Y Liu - Experimental Hematology & Oncology, 2022 - Springer
Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …
Cell penetrating peptides: classification, mechanisms, methods of study, and applications
A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …
remarkable ability to cross cell membranes and deliver various types of cargoes, including …
γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis
G Fang, Q Wang, X Yang, Y Qian, G Zhang… - Carbohydrate polymers, 2022 - Elsevier
Anterior uveitis is a sight-threatening inflammation inside the eyes. Conventional eye drops
for anti-inflammatory therapy need to be administered frequently owing to the rapid …
for anti-inflammatory therapy need to be administered frequently owing to the rapid …
Suppression of NLRP3/Caspase-1/GSDMD mediated corneal epithelium pyroptosis using melatonin-loaded liposomes to inhibit benzalkonium chloride-induced dry …
Q Lou, L Pan, S Xiang, Y Li, J Jin, J Tan… - International Journal …, 2023 - Taylor & Francis
Introduction Benzalkonium chloride (BAC) is widely employed as a preservative in eye
drops, which will cause the death of corneal epithelial cells due to ROS production, DNA …
drops, which will cause the death of corneal epithelial cells due to ROS production, DNA …
[HTML][HTML] Peptide cargo administration: current state and applications
Effective delivery of drug molecules to the target site is a challenging task. In the last decade,
several innovations in the drug delivery system (DDS) have tremendously improved the …
several innovations in the drug delivery system (DDS) have tremendously improved the …
Multicompartment systems: a putative carrier for combined drug delivery and targeting
L Gautam, P Shrivastava, B Yadav, A Jain… - Drug Discovery …, 2022 - Elsevier
In this review, we discuss recent developments in multicompartment systems commonly
referred to as vesosomes, as well as their method of preparation, surface modifications, and …
referred to as vesosomes, as well as their method of preparation, surface modifications, and …