[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …

[HTML][HTML] Lipid nanoparticles as a promising drug delivery carrier for topical ocular therapy—an overview on recent advances

S Jacob, AB Nair, J Shah, S Gupta, SHS Boddu… - Pharmaceutics, 2022 - mdpi.com
Due to complicated anatomical and physical properties, targeted drug delivery to ocular
tissues continues to be a key challenge for formulation scientists. Various attempts are …

Nanomaterial-based ophthalmic drug delivery

G Xie, S Lin, F Wu, J Liu - Advanced drug delivery reviews, 2023 - Elsevier
The low bioavailability and side effects of conventional drugs for eye disease necessitate the
development of efficient drug delivery systems. Accompanying the developments of …

[HTML][HTML] Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy

M Wu, W Huang, N Yang, Y Liu - Experimental Hematology & Oncology, 2022 - Springer
Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …

Cell penetrating peptides: classification, mechanisms, methods of study, and applications

A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis

G Fang, Q Wang, X Yang, Y Qian, G Zhang… - Carbohydrate polymers, 2022 - Elsevier
Anterior uveitis is a sight-threatening inflammation inside the eyes. Conventional eye drops
for anti-inflammatory therapy need to be administered frequently owing to the rapid …

Suppression of NLRP3/Caspase-1/GSDMD mediated corneal epithelium pyroptosis using melatonin-loaded liposomes to inhibit benzalkonium chloride-induced dry …

Q Lou, L Pan, S Xiang, Y Li, J Jin, J Tan… - International Journal …, 2023 - Taylor & Francis
Introduction Benzalkonium chloride (BAC) is widely employed as a preservative in eye
drops, which will cause the death of corneal epithelial cells due to ROS production, DNA …

[HTML][HTML] Peptide cargo administration: current state and applications

H Rohira, A Arora, P Kaur, A Chugh - Applied Microbiology and …, 2023 - Springer
Effective delivery of drug molecules to the target site is a challenging task. In the last decade,
several innovations in the drug delivery system (DDS) have tremendously improved the …

Multicompartment systems: a putative carrier for combined drug delivery and targeting

L Gautam, P Shrivastava, B Yadav, A Jain… - Drug Discovery …, 2022 - Elsevier
In this review, we discuss recent developments in multicompartment systems commonly
referred to as vesosomes, as well as their method of preparation, surface modifications, and …