The age-related changes in the functions and composition of the human body require
adjustments of drug selection and dosage for old individuals. Drug excretion via the kidneys …

The prevalence of pain and pain undertreatment in older persons, along with the many
potential detrimental consequences of undertreated pain, pose a substantial burden to the …

This study reports chronic pain prevalence in a randomly selected sample of the adult
Australian population. Data were collected by Computer-Assisted Telephone Interview …

With the aging population, an increasing number of older adults (> 65 years) will be affected
by problematic opioid use and opioid use disorder (OUD), with both illicit and prescription …

Drug dosage in the elderly requires an understanding of the age-dependent changes in
drug disposition and sensitivity. The most important pharmacokinetic alteration is a decline …

Evidence suggests a link between opioid use and kidney disease. This review summarizes
the known renal manifestations of opioid use including its role in acute and chronic kidney …

Introduction: Substance use disorder has been frequently reported to increase the risk of
infectious diseases, which might be owing to the sharing of contaminated inhalation …

In patients suffering from moderate-to-severe chronic kidney disease (CKD) or end-stage
renal disease (ESRD), subjected to hemodialysis (HD), pain is very common, but often …

Background: Several previous studies have reported an undertreatment of pain in elderly
persons with dementia. It has also been suggested that persons with dementia may be at …

In this second article of our two-part review, we focus on age-associated physiologic
changes involving the nervous, endocrine, hematologic, immune, and musculoskeletal …