RcsB, a response regulator of the FixJ/NarL family, is at the center of a complex network of
regulatory inputs and outputs. Cell surface stress is sensed by an outer membrane …

Temperature affects cellular processes at different spatiotemporal scales, and identifying the
genetic and molecular mechanisms underlying temperature responses paves the way to …

Bacterial genome evolution is characterized by gains, losses, and rearrangements of
functional genetic segments. The extent to which large-scale genomic alterations influence …

Background: Chlamydia trachomatis is a prolific human pathogen that can cause serious
long-term conditions if left untreated. Recent developments in Chlamydia genetics have …

Viruses rely on their host for reproduction. Here, we made use of genomic and structural
information to create a biomass function capturing the amino and nucleic acid requirements …

Streptococcus pyogenes (group A streptococcus [GAS]) causes 600 million cases of
pharyngitis each year. Despite this considerable disease burden, the molecular …

The genus Yersinia includes a large variety of nonpathogenic and life-threatening
pathogenic bacteria, which cause a broad spectrum of diseases in humans and animals …

Here, we describe a novel workflow combining informatic and experimental approaches to
enable evidence-based prioritising of targets from large sets in parallel. High-throughput …

The design of synthetic cells requires a detailed understanding of the relevance of genes
and gene networks underlying complex cellular phenotypes. Transposon-sequencing (Tn …

The Yersinia pestis pH 6 antigen (PsaA) forms fimbria-like structures and is required for full
virulence during bubonic plague. High temperature and low pH regulate PsaA production …