[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

V Bourganis, O Kammona, A Alexopoulos… - European Journal of …, 2018 - Elsevier
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

Inhalation drug delivery devices: technology update

M Ibrahim, R Verma… - … Devices: Evidence and …, 2015 - Taylor & Francis
The pulmonary route of administration has proven to be effective in local and systemic
delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non …

[HTML][HTML] Spray drying for the preparation of nanoparticle-based drug formulations as dry powders for inhalation

M Malamatari, A Charisi, S Malamataris, K Kachrimanis… - Processes, 2020 - mdpi.com
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance
delivery of poorly water-soluble drugs, protect drugs against degradation and achieve …

Delivery of antibiotics with polymeric particles

MH Xiong, Y Bao, XZ Yang, YH Zhu, J Wang - Advanced drug delivery …, 2014 - Elsevier
Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of
hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low …

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges

CA Ruge, J Kirch, CM Lehr - The lancet Respiratory medicine, 2013 - thelancet.com
Research in pulmonary drug delivery has focused mainly on new particle or device
technologies to improve the aerosol generation and pulmonary deposition of inhaled drugs …

Pulmonary drug delivery by powder aerosols

MY Yang, JGY Chan, HK Chan - Journal of Controlled Release, 2014 - Elsevier
The efficacy of pharmaceutical aerosols relates to its deposition in the clinically relevant
regions of the lungs, which can be assessed by in vivo lung deposition studies. Dry powder …

[HTML][HTML] Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

Y Xu, L Harinck, AG Lokras, P Gerde, E Selg… - International Journal of …, 2022 - Elsevier
Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are
attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We …

New inhaler devices-the good, the bad and the ugly

F Lavorini, GA Fontana, OS Usmani - Respiration, 2014 - karger.com
Drug delivery to the lungs is an effective way of targeting inhaled therapeutic aerosols and
treating obstructive airway diseases, such as asthma and chronic obstructive pulmonary …

[HTML][HTML] Recent advances in capsule-based dry powder inhaler technology

F Lavorini, M Pistolesi, OS Usmani - Multidisciplinary respiratory medicine, 2017 - Springer
Pulmonary drug delivery is currently the focus of accelerated research and development
because of the potential to produce maximum therapeutic benefit to patients by directly …

[HTML][HTML] Dry powder inhalers in the digitalization era: current status and future perspectives

S Xiroudaki, A Schoubben, S Giovagnoli, DM Rekkas - Pharmaceutics, 2021 - mdpi.com
During the last decades, the term “drug delivery systems”(DDSs) has almost fully replaced
previously used terms, such as “dosage forms”, in an attempt to emphasize the importance …