Amitriptyline or Not, That Is the Question: Pharmacogenetic Testing of CYP2D6 and CYP2C19 Identifies Patients with Low or High Risk for Side Effects in …

W Steimer, K Zopf, S von Amelunxen, H Pfeiffer… - Clinical …, 2005 - academic.oup.com
Background: Amitriptyline has been replaced in many countries by alternative and more
expensive drugs based on claims of improved tolerability and toxicity and despite slightly …

Toward an understanding of the protein interaction network of the human liver

J Wang, K Huo, L Ma, L Tang, D Li, X Huang… - Molecular systems …, 2011 - embopress.org
Proteome‐scale protein interaction maps are available for many organisms, ranging from
bacteria, yeast, worms and flies to humans. These maps provide substantial new insights …

[HTML][HTML] Pathway and network approaches for identification of cancer signature markers from omics data

J Wang, Y Zuo, Y Man, I Avital, A Stojadinovic… - Journal of …, 2015 - ncbi.nlm.nih.gov
The advancement of high throughput omic technologies during the past few years has made
it possible to perform many complex assays in a much shorter time than the traditional …

Gene expression signature of human HepG2 cell line

S Costantini, G Di Bernardo, M Cammarota, G Castello… - Gene, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and is
associated with various clinico-pathological characteristics such as genetic mutations and …

[HTML][HTML] Biomedical text mining and its applications

R Rodriguez-Esteban - PLoS computational biology, 2009 - journals.plos.org
This tutorial is intended for biologists and computational biologists interested in adding text
mining tools to their bioinformatics toolbox. As an illustrative example, the tutorial examines …

[HTML][HTML] Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

J Kim, SJ Hong, EK Lim, YS Yu, SW Kim… - Journal of Experimental …, 2009 - Springer
Background Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver,
with high relapse and mortality rates despite diverse treatment modalities. In this study …

[HTML][HTML] Immune–related biomarkers shared by inflammatory bowel disease and liver cancer

TB Nguyen, DN Do, TTP Nguyen, TL Nguyen… - PloS One, 2022 - journals.plos.org
It has been indicated that there is an association between inflammatory bowel disease (IBD)
and hepatocellular carcinoma (HCC). However, the molecular mechanism underlying the …

HCVpro: hepatitis C virus protein interaction database

SK Kwofie, U Schaefer, VS Sundararajan… - Infection, Genetics and …, 2011 - Elsevier
It is essential to catalog characterized hepatitis C virus (HCV) protein–protein interaction
(PPI) data and the associated plethora of vital functional information to augment the search …

[HTML][HTML] Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinoma

MH Chen, WLR Yang, KT Lin, CH Liu, YW Liu… - PloS one, 2011 - journals.plos.org
Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis. Currently,
only sorafenib is approved by the FDA for advanced HCC treatment; therefore, there is an …

Micronome revealed miR-205-5p as key regulator of VEGFA during cancer related angiogenesis in hepatocellular carcinoma

AU Toro, SK Shukla, P Bansal - Molecular Biotechnology, 2023 - Springer
The high ratio of global mortality rate to incidence rate and steep increase in incidence of
liver cancer warrants need for advancement of innovative cancer treatment and therapy for …