Role of NRF2 in ovarian cancer
G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …
[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
JKM Lim, A Delaidelli, SW Minaker… - Proceedings of the …, 2019 - National Acad Sciences
The RAS family of proto-oncogenes are among the most commonly mutated genes in
human cancers and predict poor clinical outcome. Several mechanisms underlying …
human cancers and predict poor clinical outcome. Several mechanisms underlying …
[HTML][HTML] Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer's disease
A Pinto, A Bonucci, E Maggi, M Corsi, R Businaro - Antioxidants, 2018 - mdpi.com
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
BN Chorley, MR Campbell, X Wang… - Nucleic acids …, 2012 - academic.oup.com
Cellular oxidative and electrophilic stress triggers a protective response in mammals
regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to …
regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to …
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …
Molecular mechanisms of Nrf2‐mediated antioxidant response
W Li, AN Kong - … : Published in cooperation with the University …, 2009 - Wiley Online Library
Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is
repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently …
repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently …
Transcription factors in cancer development and therapy
Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …
Mitochondria and reactive oxygen species: physiology and pathophysiology
S Bolisetty, EA Jaimes - International journal of molecular sciences, 2013 - mdpi.com
The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …
The signaling mechanism of ROS in tumor progression
WS Wu - Cancer and Metastasis Reviews, 2006 - Springer
Reactive oxygen species (ROS) are recently proposed to be involved in tumor metastasis
which is a complicated processes including epithelial–mesenchymal transition (EMT) …
which is a complicated processes including epithelial–mesenchymal transition (EMT) …