Fetal cerebrovascular responses to acute hypoxia are fundamentally different from those
observed in the adult cerebral circulation. The magnitude of hypoxic vasodilatation in the …

In lung vasculature, reversible constriction of smooth muscle cells exists in response to
acute decrease in oxygen levels (hypoxia). Progressive and irreversible structural …

One of the most complex areas in perinatal/neonatal medicine is the use of oxygen in
neonatal therapies. To address the knowledge gaps that preclude optimal, evidence-based …

This review focuses on new insights provided by gene-modified animals into the
cardiovascular pharmacology of serotonin. During their development, mice mutant for …

Long-term hypoxia (LTH) attenuates nitric oxide-induced vasorelaxation in ovine middle
cerebral arteries. Because cGMP-dependent protein kinase (PKG) is an important mediator …

Background It has been demonstrated that κ-opioid receptor agonists can reduce hypoxia–
ischemia brain injury in animal models. However, it is unclear how the κ-opioid receptor …

In the chicken embryo, acute hypoxemia results in cardiovascular responses, including an
increased peripheral resistance. We investigated whether local direct effects of decreased …

Cytosolic Ca2+ signaling dynamics are important to pulmonary arterial reactivity, and
alterations are implicated in pulmonary vascular disorders. Yet, adaptations in cellular Ca2+ …

The present study tests the hypothesis that age-related changes in patterns of agonist-
induced myofilament Ca2+ sensitization involve corresponding differences in the relative …

To address the hypothesis that maturation alters the contribution of K-channels to resting
and agonist-induced tone in small cerebral arteries, second branch middle cerebral arteries …