A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

The FAIR guiding principles for research data stewardship (findability, accessibility,
interoperability, and reusability) look set to become a cornerstone of research in the life …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

The potential for genome-wide association studies to relate phenotypes to specific genetic
variation is greatly increased when data can be combined or compared across multiple …

More than 800 published genetic association studies have implicated dozens of potential
risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we …

Species introductions of anthropogenic origins are a major aspect of rapid ecological
change globally. Research on biological invasions has generated a large literature on many …

Reactive oxygen species (ROS) are induced through a variety of endogenous and
exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by …

Background Robust replication is a sine qua non for the rigorous documentation of
proposed associations in the genome-wide association (GWA) setting. Currently …

The ratio of false-positive to false-negative findings (FP: FN ratio) is an informative metric
that warrants further evaluation. The FP: FN ratio varies greatly across different …

Background More than 1000 reports have been published in the past two decades on
associations between variants in candidate genes and risk of breast cancer. Results have …