Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19
differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

MicroRNAs (miRNAs) are small non-coding RNAs that play a critical role in regulating
diverse biological processes. Extracting functional insights from a list of miRNAs is …

Histamine is a biogenic amine with extensive effects on many cell types, including important
immunologic cells, such as antigen-presenting cells, natural killer cells, epithelial cells, and …

Histamine is a mediator of allergic inflammation released mainly from mast cells. Although
histamine strongly increases vascular permeability, its precise mechanism under in vivo …

Regulation of vascular endothelial (VE) growth factor (VEGF)–induced permeability is critical
in physiological and pathological processes. We show that tyrosine phosphorylation of …

Mast cells (MCs) promote a wide range of localized and systemic inflammatory responses.
Their involvement in immediate as well as chronic inflammatory reactions at both local and …

We studied the role of the target of rapamycin complex 2 (mTORC2) during neutrophil
chemotaxis, a process that is mediated through the polarization of actin and myosin filament …