• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted through January 2011. Searches were limited to …

Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted through January 2011. Searches were limited to …

Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with
systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …

In metazoans, transition from fetal to adult heart is accompanied by a switch in energy
metabolism-glycolysis to fatty acid oxidation. The molecular factors regulating this metabolic …

The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin …

The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …