Abstract microRNAs (miRNAs) represent a recent breakthrough regarding gene expression
regulation. They are instrumental players known to regulate post-transcriptional expression …

Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in
the pathophysiology of multiple human diseases, including those affecting the …

Viral vectors have been proven useful in a broad spectrum of gene therapy applications due
to their possibility to accommodate foreign genetic material for both local and systemic …

With the increasing insight into molecular mechanisms of cardiovascular disease, a
promising solution involves directly delivering genes, cells, and chemicals to the infarcted …

The development of gene therapy puts forward the requirements for efficient delivery of
genetic information into diverse cells. However, in some cases of transfection, especially …

Diabetes is a complex metabolic disease that exposes patients to the deleterious effects of
hyperglycemia on various organs. Achievement of normoglycemia with exogenous insulin …

Background: Cardiac bridging integrator 1 (cBIN1) organizes transverse tubule (t-tubule)
membrane calcium handling microdomains required for normal beat-to-beat contractility …

Recombinant adeno-associated virus (rAAV) is a commonly used gene therapy vector for
the delivery of therapeutic transgenes in a variety of human diseases, but pre-existing serum …

Significance: Redox homeostasis plays a pivotal role in vascular cell function and its
imbalance has a causal role in a variety of vascular diseases. Accordingly, the response of …

Regenerating an injured heart holds great promise for millions of patients suffering from
heart diseases. Since the human heart has very limited regenerative capacity, this is a …