The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …
preclinical models and clinical studies of depression have revealed an array of structural …
The synapse as a treatment avenue for Alzheimer's Disease
L Peng, I Bestard-Lorigados, W Song - Molecular psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …
[HTML][HTML] Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer's disease
BR Price, LA Johnson, CM Norris - Ageing research reviews, 2021 - Elsevier
Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases
M Bandookwala, P Sengupta - International Journal of …, 2020 - Taylor & Francis
Reactive oxygen species are generated as a by-product of routine biochemical reactions.
However, dysfunction of the antioxidant system or mutations in gene function may result in …
However, dysfunction of the antioxidant system or mutations in gene function may result in …
The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
[HTML][HTML] Ginsenoside Re inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response in beta-amyloid-challenged SH …
M Liu, X Bai, S Yu, W Zhao, J Qiao, Y Liu, D Zhao… - Molecules, 2019 - mdpi.com
Accumulation of amyloid-β (Aβ), which results in the formation of senile plaques that cause
oxidative damage and neuronal cell death, has been accepted as the major pathological …
oxidative damage and neuronal cell death, has been accepted as the major pathological …
Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress
R Ghasemi-Tarie, Z Kiasalari, M Fakour… - Metabolic Brain …, 2022 - Springer
Alzheimer's disease (AD) is presented as an age-related neurodegenerative disease with
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …
Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects
A Shahmohammadi, AM Rousta, MR Azadi… - Cytokine, 2018 - Elsevier
Systemic inflammation during infectious disorders usually accompanies chronic
complications including cognitive dysfunction. Neuroinflammation and cognitive deficit are …
complications including cognitive dysfunction. Neuroinflammation and cognitive deficit are …
[HTML][HTML] Oxidative stress as a therapeutic target in amyotrophic lateral sclerosis: Opportunities and limitations
HR Park, EJ Yang - Diagnostics, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou
Gehrig's disease, is characterized by a loss of the lower motor neurons in the spinal cord …
Gehrig's disease, is characterized by a loss of the lower motor neurons in the spinal cord …
Silencing of LncRNA BDNF-AS attenuates Aβ25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress
CC Guo, C Jiao, ZM Gao - Neurological Research, 2018 - Taylor & Francis
Objective: To explore the effects of long non-coding RNA (lncRNA) brain-derived
neurotrophic factor anti-sense (BDNF-AS) on the Aβ25-35-induced neurotoxicity in PC12 …
neurotrophic factor anti-sense (BDNF-AS) on the Aβ25-35-induced neurotoxicity in PC12 …