Inhibitory interneurons and their circuit motifs in the many layers of the barrel cortex

D Feldmeyer, G Qi, V Emmenegger, JF Staiger - Neuroscience, 2018 - Elsevier
Recent years have seen substantial progress in studying the structural and functional
properties of GABAergic interneurons and their roles in the neuronal networks of barrel …

The role of the orbitofrontal cortex in alcohol use, abuse, and dependence

DE Moorman - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Characterizing functional pathways of the human olfactory system

G Zhou, G Lane, SL Cooper, T Kahnt, C Zelano - elife, 2019 - elifesciences.org
The central processing pathways of the human olfactory system are not fully understood.
The olfactory bulb projects directly to a number of cortical brain structures, but the distinct …

Identity-specific reward representations in orbitofrontal cortex are modulated by selective devaluation

JD Howard, T Kahnt - Journal of Neuroscience, 2017 - Soc Neuroscience
Goal-directed behavior is sensitive to the current value of expected outcomes. This requires
independent representations of specific rewards, which have been linked to orbitofrontal …

Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

M Dubois, J Habicht, J Michely, R Moran, RJ Dolan… - Elife, 2021 - elifesciences.org
An exploration-exploitation trade-off, the arbitration between sampling a lesser-known
against a known rich option, is thought to be solved using computationally demanding …

Interactions between human orbitofrontal cortex and hippocampus support model-based inference

F Wang, G Schoenbaum, T Kahnt - PLoS Biology, 2020 - journals.plos.org
Internal representations of relationships between events in the external world can be utilized
to infer outcomes when direct experience is lacking. This process is thought to involve the …

Childhood trauma is associated with elevated anhedonia and altered core reward circuitry in major depression patients and controls

J Fan, W Liu, J Xia, S Li, F Gao, J Zhu… - Human brain …, 2021 - Wiley Online Library
Childhood trauma (CT) is a well‐established risk factor for major depressive disorder (MDD).
However, the underlying mechanism linking CT and MDD remains not fully understood. The …

Noradrenaline blockade specifically enhances metacognitive performance

TU Hauser, M Allen, N Purg, M Moutoussis, G Rees… - Elife, 2017 - elifesciences.org
Impairments in metacognition, the ability to accurately report one's performance, are
common in patients with psychiatric disorders, where a putative neuromodulatory …

Multi-scale neural decoding and analysis

HY Lu, ES Lorenc, H Zhu, J Kilmarx… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Complex spatiotemporal neural activity encodes rich information related to
behavior and cognition. Conventional research has focused on neural activity acquired …

Beta-blocker propranolol modulates decision urgency during sequential information gathering

TU Hauser, M Moutoussis, N Purg… - Journal of …, 2018 - Soc Neuroscience
Arbitrating between timely choice and extended information gathering is critical for effective
decision making. Aberrant information gathering behavior is thought to be a feature of …