[HTML][HTML] SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
Repurposing drugs for the treatment of COVID-19 and its cardiovascular manifestations
RS Wang, J Loscalzo - Circulation research, 2023 - Am Heart Assoc
COVID-19 is an infectious disease caused by SARS-CoV-2 leading to the ongoing global
pandemic. Infected patients developed a range of respiratory symptoms, including …
pandemic. Infected patients developed a range of respiratory symptoms, including …
Virus-host interaction networks as new antiviral drug targets for IAV and SARS-CoV-2
N Chen, B Zhang, L Deng, B Liang… - Emerging microbes & …, 2022 - Taylor & Francis
ABSTRACT Currently, SARS-CoV-2, especially the Omicron strain, is ravaging the world
and even co-infecting human beings with IAV, which is a serious threat to human public …
and even co-infecting human beings with IAV, which is a serious threat to human public …
[HTML][HTML] NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
YA Su, HY Chiu, YC Chang, CJ Sung, CW Chen… - Journal of Cell …, 2023 - rupress.org
Mitochondria are dynamic organelles regulated by fission and fusion processes. The fusion
of membranes requires elaborative coordination of proteins and lipids and is particularly …
of membranes requires elaborative coordination of proteins and lipids and is particularly …
A geometric deep learning framework for drug repositioning over heterogeneous information networks
Drug repositioning (DR) is a promising strategy to discover new indicators of approved
drugs with artificial intelligence techniques, thus improving traditional drug discovery and …
drugs with artificial intelligence techniques, thus improving traditional drug discovery and …
[HTML][HTML] Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
Summary G3BP1/2 are paralogous proteins that promote stress granule formation in
response to cellular stresses, including viral infection. The nucleocapsid (N) protein of …
response to cellular stresses, including viral infection. The nucleocapsid (N) protein of …
[HTML][HTML] Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
F Mihalič, L Simonetti, G Giudice, MR Sander… - Nature …, 2023 - nature.com
Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.
Studies of motif-mediated interactions therefore provide insight into virus-host …
Studies of motif-mediated interactions therefore provide insight into virus-host …
[HTML][HTML] Evolutionary history of type II transmembrane serine proteases involved in viral priming
Type II transmembrane serine proteases (TTSPs) are a family of trypsin-like membrane-
anchored serine proteases that play key roles in the regulation of some crucial processes in …
anchored serine proteases that play key roles in the regulation of some crucial processes in …
[HTML][HTML] The ACE2 receptor for coronavirus entry is localized at apical cell—cell junctions of epithelial cells
F Rouaud, I Méan, S Citi - Cells, 2022 - mdpi.com
Transmembrane proteins of adherens and tight junctions are known targets for viruses and
bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of …
bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of …
[HTML][HTML] Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets
F Mihalič, C Benz, E Kassa, R Lindqvist… - Nature …, 2023 - nature.com
The virus life cycle depends on host-virus protein-protein interactions, which often involve a
disordered protein region binding to a folded protein domain. Here, we used proteomic …
disordered protein region binding to a folded protein domain. Here, we used proteomic …