Background In case of bleeding patients and in acute care, the assessment of residual direct
oral anticoagulant (DOAC) activity is essential for evaluating the potential impact on …

Anticoagulant drugs (ie, unfractionated heparin, low-molecular-weight heparins, vitamin K
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …

Dabigatran, rivaroxaban, apixaban, and edoxaban are direct oral anticoagulants (DOACs)
that are increasingly used worldwide. Taking into account their widespread use for the …

This is a narrative review of the published evidence for bleeding management in critically ill
patients in different clinical settings in the intensive care unit (ICU). We aimed to describe …

Introduction Timely measurement of direct oral anticoagulants (DOACs) is challenging,
though clinically important. We tested the hypotheses, that thromboelastometry is able to …

Essentials• A rapid test to detect thrombin inhibition by dabigatran would be valuable in
acute situations.• A thrombin‐based trigger was applied in whole blood using rotation …

A rapid and reliable assessment of the dabigatran effect is desirable in dabigatran treated
patients with uncontrolled bleeding or before acute surgery. The aim of this study was to …

Thromboelastometry (ROTEM®) is an advancement of the classical thromboelastography.
Several technical enhancements made already the semiautomated ROTEM® delta device …

BACKGROUND: Incomplete reversal with a recommended 5-g dose of idarucizumab has
been reported in patients with excessively high dabigatran concentrations. A timely …

Atrial fibrillation (AF) accounts for 40% of all cardiac arrhythmias and is associated with a
high risk of stroke and systemic thromboembolic complications. Dabigatran, rivaroxaban …